Car T therapy

Car T therapy

CAR T-Cell Therapy for Multiple Myeloma

Researchers are finding new ways to fight multiple myeloma, including a new treatment called CAR T-cell therapy. It's still experimental, but you may get a chance to join a clinical trial if your other treatments aren't working.
CAR T-cell therapy works differently from other cancer treatments. It trains your immune system to find and kill cancer. And it's tailor-made for you.
What Happens in CAR T-Cell Therapy?
First, doctors collect immune cells called T cells from your blood. These cells are genetically engineered to make a chimeric antigen receptor (CAR). CARs seek proteins on the surface of cancer cells and attach to them.
Technicians multiply these engineered immune cells in a lab until there are millions of them. Your doctor puts them back into your body through an IV, where they seek out and kill cancer cells. CAR T cells can stay alive in your body and keep attacking cancer cells for many years.

CAR T-cell treatments for multiple myeloma target a protein called B-cell maturation antigen (BCMA). BCMA is on the surface of myeloma cells but not healthy cells.

How Well Does It Work?

Clinical trials for multiple myeloma so far have been small, but promising. One One U.S. study of a CAR T-cell therapy included 21 people who had already tried an average of seven other treatments. Eighteen of them got a higher dose of the treatment. About 56% of those 18 people had complete remissions, meaning there was no longer any sign of their cancer.
A Chinese study included 35 people with multiple myeloma. About 94% showed signs of remission after CAR T-cell therapy.

These two studies are the earliest types of clinical trials, called phase I, which are done to check the treatment's safety, not how well it works. More studies that are longer and have larger groups of people are needed to show this treatment works for multiple myeloma and how long people live who get it.
Right now there are more than 20 clinical trials in various stages across the U.S. To learn more about them, visit the U.S. National Library of Medicine’s Clinical Trials.gov site.
Researchers are finding new ways to fight multiple myeloma, including a new treatment called CAR T-cell therapy. It's still experimental, but you may get a chance to join a clinical trial if your other treatments aren't working.
CAR T-cell therapy works differently from other cancer treatments. It trains your immune system to find and kill cancer. And it's tailor-made for you.

What Happens in CAR T-Cell Therapy?

First, doctors collect immune cells called T cells from your blood. These cells are genetically engineered to make a chimeric antigen receptor (CAR). CARs seek proteins on the surface of cancer cells and attach to them.
Technicians multiply these engineered immune cells in a lab until there are millions of them. Your doctor puts them back into your body through an IV, where they seek out and kill cancer cells. CAR T cells can stay alive in your body and keep attacking cancer cells for many years.