CAR T-Cell Therapy for Leukemia

Indication: R/R B-cell Acute Lymphoblastic Leukemia
Therapy: CAR-T treatment
Inclusion & exclusion criteria:
Inclusion Criteria:
1.Patients with CD19+/CD22+ Refractory or Relapsed B-ALL(At least 2 prior combination chemotherapy regimens)
2.To be aged 3 to 75 years
3.ECOG score ≤2
4.Women of childbearing potential must have a urine pregnancy test taken and proven negative prior to the treatment. All patients agree to use reliable methods of contraception during the trial period and until follow-up for the last time.
Exclusion Criteria:
1.Intracranial hypertension or unconsciousness
2.Respiratory failure
3.Disseminated intravascular coagulation
4.Hematosepsis or Uncontrolled active infection
5.Uncontrolled diabetes
Attention: This criteria is only for your reference, the final decision should be done by the hematologist in the hospitals.
CR Rate: CD19 90%
CD22 70%
Time frame:
1.Examination & test: one week
2.Pre-treatment & T-Cell Collection: one week
3.T-Cell preparation & return: two-three weeks
4.1st Effectiveness analysis: two weeks
5.2nd Effectiveness analysis: two weeks